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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease
Hyeon Jeong Kim, Haelee Kim, Jaeyoung Song, Jun Young Hong, Elijah Hwejin Lee, Ashwini M. Londhe, Ji Won Choi, Sun Jun Park, Eunseok Oh, Heeseok Yoon, Hoosang Hwang, Dongyup Hahn, Kyungjin Jung, Sugyeong Kwon, Tara Man Kadayat, Min Jung Ma, Jeongmin Joo, Jina Kim, Jae Hyun Bae, Hayoung Hwang, Ae Nim Pae, Sung Jin Cho, Jong-Hyun Park, Jungwook Chin, Heonjoong Kang, Ki Duk Park
Theranostics 2024; 14(16): 6088-6108. doi:10.7150/thno.96707
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Research Paper
Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke
Jing Ye, Xinyuan Bi, Shiyu Deng, Xianghui Wang, Ze Liu, Qian Suo, Jiao Wu, Haoran Chen, Yong Wang, Kun Qian, Rubing Shi, Jing Zhao, Guo-Yuan Yang, Jian Ye, Yaohui Tang
Theranostics 2024; 14(15): 6071-6087. doi:10.7150/thno.100090
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Research Paper
Subarachnoid hemorrhage distinctively disrupts the glymphatic and meningeal lymphatic system in beagles
Jiaqi Wang, Tao Lv, Feng Jia, Yang Li, Weiwei Ma, Zhi-Peng Xiao, Weifeng Yu, Heng Zhao, Xiaohua Zhang, Qin Hu
Theranostics 2024; 14(15): 6053-6070. doi:10.7150/thno.100982
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Research Paper
p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver
Lina Zhao, Hongfeng Yuan, Yufei Wang, Chunyu Hou, Pan Lv, Huihui Zhang, Guang Yang, Xiaodong Zhang
Theranostics 2024; 14(15): 6036-6052. doi:10.7150/thno.99407
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Research Paper
Multifunctionally disordered TiO2 nanoneedles prevent periprosthetic infection and enhance osteointegration by killing bacteria and modulating the osteoimmune microenvironment
Yangmengfan Chen, Liqiang Zhou, Ming Guan, Shue Jin, Peng Tan, Xiaoxue Fu, Zongke Zhou
Theranostics 2024; 14(15): 6016-6035. doi:10.7150/thno.98219
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Research Paper
Nicotinamide mononucleotide enhances fracture healing by promoting skeletal stem cell proliferation
Yitian Shi, Jiayin Peng, Mengfan Liu, Xiling Qi, Siyu Li, Qiangqiang Li, Qing Jiang, Liming Zheng, Jiankun Xu, Yun Zhao, Yifeng Zhang
Theranostics 2024; 14(15): 5999-6015. doi:10.7150/thno.98149
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

Rationale: Alzheimer's disease (AD) is a progressive neurodegenerative disease accompanied by neurotoxicity, excessive inflammation, and cognitive impairment. The peroxisome proliferator-activated receptor (PPAR) δ is a potential target for AD. However, its regulatory mechanisms and therapeutic potential in AD remain unclear. We aimed to investigate if the activation of PPARδ using a highly selective and potent agonist could provide an effective therapeutic strategy against AD. Methods: We synthesized a novel PPARδ agonist, 5a, containing a selenazole group and determined the X-ray....
Rationale: Stroke induces metabolic changes in the body, and metabolites have become potential biomarkers for stroke. However, the specific metabolites involved in stroke and the mechanisms underlying brain injury during stroke remain unclear. Methods: Surface-enhanced Raman spectroscopy (SERS) and liquid chromatography-mass spectrometry (LC‒MS) analysis of clinical serum samples from 69 controls and 51 ischemic stroke patients who underwent reperfusion within 24 hours were performed to identify differentially abundant metabolites. Mice were subjected to transient middle cerebral artery occlusion....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Unraveling In vivo Potential of Curcumin-loaded Graphene Quantum Dots on Drug Delivery and Release Kinetics Aspects of Cancer Treatment
Mochamad Z. Fahmi, Siti F. A. Sugito, Aswandi Wibrianto, Siska Novania, Shinta Widyastuti, Musbahu Adam Ahmad, Satya C. W. Sakti, Lee H. Voon
Nanotheranostics 2024; 8(4): 521-534.
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